翻訳と辞書 Words near each other ・ Epigenetics in insects ・ Epigenetics in learning and memory ・ Epigenetics in stem-cell differentiation ・ Epigenetics of autism ・ Epigenetics of cocaine addiction ・ Epigenetics of depression ・ Epigenetics of diabetes Type 2 ・ Epigenetics of human development ・ Epigenetics of human herpesvirus latency ・ Epigenetics of neurodegenerative diseases ・ Epigenetics of physical exercise ・ Epigenetics of plant growth and development ・ Epigenetics of schizophrenia ・ Epigenius ・ Epigenome ・ Epigenome editing ・ Epigenomics ・ Epigenomics (journal) ・ Epigenomics AG ・ Epiglaea ・ Epiglaea apiata ・ Epiglaea decliva ・ Epigloeaceae ・ Epiglottal ejective ・ Epiglottal flap ・ Epiglottal stop ・ Epiglottic vallecula ・ Epiglottis ・ Epiglottitis ・ Epignosis Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Epigenome editing ： ウィキペディア英語版 Epigenome editing Epigenome editing is a type of genetic engineering in which the epigenome is modified at specific sites using engineered molecules targeted to those sites (as opposed to whole-genome modifications). “Editing” epigenomic features in this manner allows researchers to determine the exact biological role of an epigenetic modification at the site in question. The engineered proteins used for epigenome editing are composed of a DNA binding domain that target specific sequences and an effector domain that modifies epigenomic features. Currently, two major groups of DNA binding proteins have been predominantly used for epigenome editing: Transcription Activator-Like Effectors (TALEs) and nuclease deficient Cas9 fusions (CRISPR). == General concept == Comparing genome-wide epigenetic maps with gene expression has allowed researchers to assign either activating or repressing roles to specific modifications. The importance of DNA sequence in regulating the epigenome has been demonstrated by using DNA motifs to predict epigenomic modification. Further insights into mechanisms behind epigenetics have come from in vitro biochemical and structural analyses. Using model organisms, researchers have been able to describe the role of many chromatin factors through knockout studies. However knocking out an entire chromatin modifier has massive effects on the entire genome, which may not be an accurate representation of its function in a specific context. As one example of this, DNA methylation occurs at repeat regions, promoters, enhancers, and gene bodies. Although DNA methylation typically correlates with gene repression, methylation has also been shown to play a role in gene splicing. The ability to directly target and edit individual methylation sites is critical to determining the exact function of DNA methylation at a specific site. Epigenome editing is a powerful tool that allows this type of analysis. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Epigenome editing」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.